Generated static export from Obsidian-friendly vault markdown
ClinPharm Vault

Phase 2b Study of EVO756 in Adults With Moderate to Severe Chronic Spontaneous Urticaria (CSU)

Study Snapshot

  • Program: EVO756
  • Study ID(s): NCT06873516
  • Phase: Phase 2
  • Indication: Chronic Spontaneous Urticaria
  • Status: Recruiting
  • Sponsor: Evommune, Inc.

Design

  • Study type: INTERVENTIONAL
  • Randomization / allocation: RANDOMIZED
  • Intervention model: PARALLEL
  • Masking: QUADRUPLE
  • Primary purpose: TREATMENT
  • Enrollment: 160 (ESTIMATED)

Population

  • Conditions: Chronic Spontaneous Urticaria
  • Sex: ALL
  • Age range: 18 Years to None
  • Healthy volunteers: False
  • Summary: This study will evaluate the efficacy and safety of different doses of EVO756 in adults with moderate to severe chronic spontaneous urticaria (CSU).

Operational design summary

  • Arms represented in current CT.gov export: 4
  • Active dose regimens represented in current local source layer: 3
  • Total study enrollment in CT.gov: 160 (ESTIMATED)
  • Design interpretation: Global randomized, double-blind, placebo-controlled phase 2b CSU dose-ranging study of oral EVO756.
  • Per-arm sample size summary: Evommune trial-initiation source states approximately 160 patients will be enrolled and randomized to one of three active dose regimens or placebo; exact arm-specific counts are not explicitly stated in the current local source text.
  • Arm-size evidence source: Evommune CSU phase 2b trial-initiation PDF cached locally.

Arms

Arm Type Dose Frequency Route Description N Evidence status
Dose 1 EXPERIMENTAL Dose 1 NR Oral Orally administered EVO756, dose 1 NR Summary-level arm-size evidence exists, but exact N is not mapped to this CT.gov arm label in the current local layer
Dose 2 EXPERIMENTAL Dose 2 NR Oral Orally administered EVO756, dose 2 NR Summary-level arm-size evidence exists, but exact N is not mapped to this CT.gov arm label in the current local layer
Dose 3 EXPERIMENTAL Dose 3 NR Oral Orally administered EVO756, dose 3 NR Summary-level arm-size evidence exists, but exact N is not mapped to this CT.gov arm label in the current local layer
Placebo control PLACEBO_COMPARATOR NR NR Oral Orally administered placebo control NR Summary-level arm-size evidence exists, but exact N is not mapped to this CT.gov arm label in the current local layer

Endpoints

  • Primary outcomes:
  • Mean change from baseline in UAS7 (time frame: Week 12)

Clinical Pharmacology Findings

  • PK: Not clearly summarized in the currently linked local source snippets.
  • PD: Not clearly summarized in the currently linked local source snippets.
  • Linked manuscripts: No trial-level primary publication is explicitly linked in the current registry.

Safety Findings

  • Safety detail is not strongly enriched beyond the current CT.gov/source-registry layer.

Linked Evidence

  • CT.gov page: https://clinicaltrials.gov/study/NCT06873516
  • Local CT.gov cache: raw/clinicaltrials/markdown/NCT06873516.md

Interpretation

  • Verified facts: this page reflects the current local registry and CT.gov inventory export without inferring unsupported arm sizes or endpoint results.
  • Interpretation: this trial is currently represented mainly by CT.gov and any linked sponsor-source artifacts; manual enrichment is still needed for a richer narrative page.
  • Open questions:
  • Some studies still lack exact arm-specific N in the current promoted evidence layer even when allocation schema or total enrollment is visible.
  • No explicit trial-level primary manuscript is currently linked in the registry.
  • No sponsor artifact is explicitly linked to this trial by identifier in the current registry.

Provenance

  • Source type: ClinicalTrials.gov inventory with linked sponsor/publication registry where available
  • Primary source(s):
  • NCT06873516
  • ../raw/clinicaltrials/markdown/NCT06873516.md
  • ../inventories/source_registry.json
  • Supporting source(s):
  • ../inventories/ctgov_priority_trials.json
  • Last verified: 2026-04-08
  • Verification status: Partial

Change Log

  • 2026-04-08: Generated or refreshed this study page from the v2 source registry and CT.gov inventory.